Catanionic Vesicles

Figure 1. (a) Photoreversible vesicle rupture and re-formation using light-responsive surfactants, measured with light scattering intensity, (b) cryoTEM images of photoresponsive catanionic vesicles, (c) transfection of NIH 3T3 cells with eGFP DNA encapsulated in photoreversible vesicles, and (d) photo-induced DNA compaction upon vesicle formation. Similar experiments of photo-initiated DNA release from the vesicle carrier are shown below.

Selected Publications:

1. Liu, Y.-C.; Le Ny, A.-L.M.; Schmidt, J.; Talmon, Y.; Chmelka, B.F.; Lee, C.T. “Photo-Assisted Gene Delivery Using Light-Responsive Catanionic Vesicles” Langmuir 2009, 25, 5713

2. Le Ny, A.-L.M.; Lee, C.T. “Conformation and Dynamics of DNA Molecules During Photoreversible Condensation” Biophys. Chem. 2009, 142, 76

3. Donaldson, S.H.; Lee, C.T.; Chmelka, B.F.; Israelachvili, J.N. “General hydrophobic interaction potential for surfactant/lipid bilayers from direct force measurements between light-modulated bilayers” Proc. Nat. Acad. Sci. 2011, 108, 15699